PERSISTENT ORGANIC POLLUTANTS ASSOCIATED WITH METABOLIC ABNORMALITIES IN SEEMINGLY HEALTHY PEOPLE

Persistent organic pollutants--POPS--are pervasive in the environment and accumulate in our bodies. Pesticides, pharmaceuticals and many industrial chemicals contribute to this potentially toxic tide.

Some common organic pollutants

Credit CunhaEnviroSci

In an earlier post, I reported on findings by epidemiologist Miquel Porta and his colleagues revealing that ten percent of Americans have 10 or more different POPS in our blood at abnormally high concentrations.

Porta and his team are now studying the impacts of these long-lived organic compounds that many of us unknowingly carry in our bodies and bloodstream.

His most recent findings, reported in the American Journal of Epidemiology, reveal a strong correlation between people's toxic loads and metabolic abnormalities such as high blood pressure, insulin resistance, high blood sugar, unhealthy lipid profiles, and chronic inflammation--factors that increase the risk of metabolic syndrome, diabetes and heart disease.

Porta and his colleagues at the Hospital del Mar Medical Research Institute in Barcelona (IMIM), and the Autonomous University of Barcelona, evaluated 860 people enrolled in the Catalan Health Interview Survey. Participants included obese and normal-weight men and women from the age of 18 to 74. Statistical analyses controlled for the effects of age, sex, BMI, educational level and social-economic status. It's the first study looking at the relationship between POPs and metabolic abnormalities in  normal-weight individuals.

"The take-home message of our study," says Porta, "is that POPs contribute to cause unhealthy metabolic phenotypes as well as the metabolic syndrome."

 Intriguingly, the correlation was stronger for people of normal weight than for obese people. This may help to explain why many people of normal weight turn out to be metabolically unhealthy, and why some obese people remain metabolically normal.

It wasn't  a small effect--people of normal weight carrying high loads of POPs were four times more likely to be metabolically unhealthy than normal-weight peers with low toxic loads. Obese individuals with high toxic loads were 1.4 times as likely to suffer from metabolic abnormalities than those with low levels of toxins in their blood. And regardless of weight, metabolically unhealthy people carried nearly twice the load of toxins than their healthy peers.

A separate research study reports that normal-weight people who are metabolically unhealthy have three times the risk of heart attack, stroke or death compared to their metabolically healthy, normal-weight peers.

Although we are all exposed to organic pollutants from many sources--the air we breathe, the water we drink, furniture, fabrics, food containers and many other sources, the authors point out that fatty animal foods are the biggest source, and one that we can control by what we choose to eat.

They add, however, that individual efforts to eat a healthy diet and maintain a healthy weight are only part of the solution. Government action to minimize the accumulation of POPs and other toxins in the workplace, consumer goods and the environment are also needed, as well as similar efforts by private companies.

"Individual habits play a role, but so do public and private policies," says Porta, "that is, polices of governments and companies that have been shown to decrease 'internal contamination' by POPs."

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You can access the abstract of Porta's journal article at this URL.

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IN U.S. EXPOSURE TO HORMONE DISRUPTING CHEMICALS COSTS HUNDREDS OF BILLIONS PER YEAR

Following up on my recent post "Ten Percent of US have high concentrations of ten or more toxins in our blood,", here's a new study that calculates the costs to the U.S. economy from the burden of disease that some of those chemicals cause.

Plastic bottles--one of many sources 

of endocrine-disrupting chemicals

Credit: Velka/Shutterstock (public domain)

Writing in The Lancet Diabetes and Endocrinology, October 17, researchers at the New York University Medical Center say that even a conservative estimate of the diseases and conditions--including birth defects, autism, attention-deficit disorder, intellectual disability, infertility, obesity, diabetes, heart disease and stroke--caused by exposure to these toxins puts their cost to the economy at $340 billion. That's 2.3 percent of the U.S. Gross Domestic Product (GDP).

Flame retardants alone (found in building insulation, fabrics, furniture and electronics) account for more than $200 billion of those health-related costs.

The researchers say this is the first assessment of the overall costs to the U.S. economy from the buildup of endocrine-disrupting substances in the population.

The major sources of these chemicals include plastic bottles, the lining of metal food cans, detergents, flame retardants, toys, pesticides and cosmetics. These pervasive chemicals build up in our bodies over time. They can impair fetal development in the womb, especially the brain and nervous system, and lead to a variety of diseases in adults.

These chemicals are pervasive and extremely difficult to avoid. To address the problem at the policy level, the authors call for more proactive testing and tighter regulation, starting with the Environmental Protection Agency (EPA). They point out that people living in Europe, where these substances are more strongly regulated, have less exposure, lower levels in the bodies and blood, and reduced risk of disability and disease.

At the personal level, they recommend steps such as not microwaving food in plastic containers or covered by plastic wrap, avoiding containers with the number 3, 6 or 7 on the bottom, which contain phthalates and using fragrance free or "all natural" cosmetics.

You can find more ways to minimize your and your family's exposure to endocrine disrupting chemicals here.

This may seem a daunting or even impossible task, given how ubiquitous these chemicals have become. However, new research shows that avoiding common sources of endocrine disrupting chemicals can quickly reduce levels in the body