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Monday, April 30, 2018

PORTUGAL GENERATES A SURPLUS OF RENEWABLE ENERGY -- WHAT ARE WE WAITING FOR?

Portugal, home to 10 million people, surged to the front of the pack in terms of renewable energy in March of this year. Using a combination of hydro, wind and solar generation, it produced more than enough electricity to power its 3.6 million households, plus businesses, industry and transport. It exported a surplus of 4.8 percent of its electricity--878 gigawatt-hours--to other European countries.

Portugal's use of renewable energy in March kept 1.8 million tons of climate-destabilizing CO2 out of the atmosphere.

Many other countries, including Sweden, Costa Rica and Germany, are moving rapidly towards meeting all or most of their power needs with renewables. You can read about Scotland's successes here.

Portugal's Alto Minho Wind Farm Under Construction
Credit: BBC News

Portugal's per capita Gross Domestic Product (GDP) is $30,300 per year, just about half that of the United States ($59,500). If they can do it, why can't we?

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Labels: Costa Rica, electricity, Germany, hydro, Portugal, renewable energy, renewables, Scotland, solar, Sweden, United States, US, wind, wind power

Thursday, April 26, 2018

FASCINATING VIRTUAL EXOPLANET TOUR

Just a quick link to let you know about a beautifully done interactive virtual reality video taking you to six of the thousands of exoplanets astronomers have discovered. While you explore, conditions on each planet are explained by a researcher studying it. Produced by the University of Exeter in the UK with the help of animators Engine house VFX, it's been viewed by more than a million people so far. Great fun.

What the surface of Trappist 1f migh look like
Credit NAPA/JPL

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Labels: exoplanets, surface, tour, virtual reality, virtual tour

Wednesday, April 25, 2018

THE COP WHO DIDN'T SHOOT--A CANADIAN OF COURSE

The contrast couldn't be greater. When Canadian police officer Constable Ken Lam tracked down Alek Minassian, the suspect charged with running down multiple pedestrians in Toronto on April 23, Minassian did everything he could to provoke the officer into shooting him. Minassian held an object that looked like a gun in his hand and pointed it towards the officer. He twice reached towards his pocket, then quickly raised his hand as if he were pulling and pointing a gun.

Minassian tries to provoke Canadian police officer to shoot him
Credit: CBC.ca

"Kill me," Minassian demanded.

"No. Get down," the officer replied.

"I have a gun in my pocket."

"I don't care," said the officer. "Get down."

You can view the video here.

In it, the officer calmly turns off his car's siren, holsters his gun, advances towards the suspect with his baton raised, and arrests him. No shots fired. No violence. Absolute professionalism.

I can't help but compare this with the dozens of videos I've viewed of similar situations here in the United States. Videos in which far less threatening situations escalate in seconds and conclude in a barrage of shots and a dead body, often found to be unarmed. Here's an example, one of far too many.

The US has about ten times more citizens than Canada. Canadian police kill an average of 25 people a year. US police kill more than 1000 people every year. According to a recent study, that represents more than 50,000 years of life lost (YLL), most of it by the early deaths of young Black men. Clearly, something is very different about police-suspect relations in the US and Canada (and most other developed countries).

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You can read earlier posts about police killings in the US here and also here.









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Labels: arrest, Canada, police, police killings, Toronto, United States, US, violence, years of life lost, YLL

WHAT "MAKE AMERICA GREAT AGAIN" REALLY MEANS

I finally get it. To use the current phrase, I'm "woke." I've come to understand what Trump and his supporters mean when they shout "Make America Great Again!"

I've been confused since I first started seeing MAGA on signs and baseball caps and hearing the chant. What Trump was selling--fear, anger, belligerence, racism, xenophobia--didn't seem great to me. But something obviously resonated with his fans.

To me, great is the superlative of good. When I think of something great, it evokes images of the best of something positive, creative, constructive, beautiful; Usain Bolt is a great sprinter, the Beatles were a great band, Moby Dick is a great novel, Casablanca a great movie. You get the idea.

But what I've come to realize is that to Trump and his friends great has a very different meaning. Synonyms would be powerful, dominant, commanding, controlling, top dog, boss. To him and them, a great nation doesn't have to be democratic, just, equitable, prosperous, peaceful, inspiring, sustainable or anything else good. It just needs to be powerful--ready, willing and able to throw its weight around. The biggest, meanest bully on the block.

You can read a succinct and frightening corroboration of this from some Trump associates here.

So when Trump tweets, "Russia vows to shoot down any and all missiles fired at Syria. Get ready Russia, because they will be coming, nice and new and 'smart,'" his supporters love it. He's demonstrating his and, by reflection, their dominance.

Or for another data point, check out this list of despots and dictators whom Trump admires.

Or this tweet:

"North Korean Leader Kim Jong Un just stated that the “Nuclear Button is on his desk at all times.” Will someone from his depleted and food starved regime please inform him that I too have a Nuclear Button, but it is a much bigger & more powerful one than his, and my Button works!"

I get it. Our nukes are bigger and more powerful than yours. MAGA!

Credit: R.J. ORIEZ/U.S. AIR FORCE PHOTO

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Trump outdid himself with his latest MAGA tweet to Iran:



Donald J. Trump

Donald J. Trump

@realDonaldTrump

To Iranian President Rouhani: NEVER, EVER THREATEN THE UNITED STATES AGAIN OR YOU WILL SUFFER CONSEQUENCES THE LIKES OF WHICH FEW THROUGHOUT HISTORY HAVE EVER SUFFERED BEFORE. WE ARE NO LONGER A COUNTRY THAT WILL STAND FOR YOUR DEMENTED WORDS OF VIOLENCE & DEATH. BE CAUTIOUS!
5:24 AM · Jul 23, 2018









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Labels: bully, bullying, dominance, great, MAGA, make America great again, power, threat, threats, Trump

Sunday, March 25, 2018

VOICES OF AMERICA

The contrast couldn’t have been greater. Flashing on one screen were the rigid faces slogans and fear-mongering screed of NRA spokesmen, culminating with the iconic image of the now long dead Charlton Heston holding a rifle above his head and chanting “From my cold dead hands!” 

On the other and on the live stage below were the young, amazingly eloquent and life-affirming faces and voices, one after another, of high school students and others from across the country who gathered in Washington, D.C. yesterday to ignite nothing less than a true Childrens’ Crusade to take back their country from those same few but powerful “cold dead hands” whose choke-hold on American politics for decades has prevented any reasonable gun-control legislation.

 March for Our Lives, Washington, DC 3/24/18
Credit: Rosa Pineda/Creative Commons

Combining a healthy blend of passion and reason, their repeated call, “Enough is Enough” as well as the spoken and unspoken theme underlying all their messages--“Choose Life-- reflected, at times, both the religious fervor and sophisticated political sensibility which characterized and energized the Civil Rights, Free Speech and anti-war movements which transformed America more than a half-century ago.

Dominating both the rhetoric and the blizzard of signs being waved in the bright Washington sunshine was a truly refreshing and deeply American faith in the power of individual citizens to effect change. While calling for a ‘revolution’ in politics and society, and while calling-out, sometimes by name, politicians who reflexively do the bidding of the NRA and the powerful gun lobby, these young citizens assumed and asserted their right to protest, demand and, most importantly, achieve the change and protection from gun violence they and a great majority of others want and need from their government.

Nowhere in sight was the cynicism, resignation and apathetic acceptance dominating the current political scene. Nor the angry, demeaning tweets and name-calling. Instead, the flavor was one of optimism and hope. Of belief that the system, though corrupted by deceit, wealth and privilege, could be reformed by the sheer will of the people expressed through the ballot box. With the Capitol dome as backdrop, and tens of thousands of marchers cheering and chanting in front of them, along with sister demonstrations occurring across the nation and world, at that moment it truly seemed possible.

Why the massacre at Marjory Douglas Stoneman High has produced this level of response when all the others, Columbine, Sandy Hook, Las Vegas and elsewhere have quickly faded from public consciousness, with only “thoughts and prayers” from elected officials as a result, is still unclear. As are the ultimate political and policy outcomes that will emerge from this latest tragedy. What is clear, however, is that a corner seems to have been turned in what has appeared up to now to be an intractable debate. Suddenly, room and pressure may have emerged for the passage of effective legislation on background checks and the availability of assault weapons.

The voices were neither fearful nor divisive, not nationalistic or exclusionary, but
fresh, authentic and full of promise—a hopeful and idealistic America we’d almost forgotten and which we’ve longed for and needed to hear again.

Les Adler
Posted by zerospinzone at 4:42 PM No comments:
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Labels: anti-war, children's march, Civil Rights, Enough is Enough, Free Speech, gun control, guns, hope, March for our lives, march on Washington, NRA, optimism, Stoneman

Thursday, March 08, 2018

WHAT'S THAT SMELL? YOUR POLITICS MAY FOLLOW YOUR NOSE!

You've arrived at your current political stance through a thoughtful integration of your family values, personal experience, education, moral development, and social and economic observations, right?

Not very likely, implies new research about the relationship between how people react to body odors and their politics. If you are disgusted by smells such as sweat or urine, you may very well be drawn to authoritarian political leaders like Donald Trump.

 Trump shows his disgust

Remember Trump's reaction to Hillary Clinton's bathroom break during the last Democratic debate?

“I know where she went, it’s disgusting, I don’t want to talk about it. No, it’s too disgusting. Don’t say it, it’s disgusting . . ."

I have no way of knowing if Trump's frequent verbal and facial expressions of disgust--at women, immigrants, minorities, blood, sweat, breastfeeding, people eating, babies, reporters, weakness and who knows what else, are genuine or feigned. But either way, he knows his audience.

Evidence for a link between finding body odors repugnant and authoritarian politics and despotic leadership comes from a series of studies carried out by researchers in Sweden and Greece. They used a carefully designed set of questions to measure the degree to which online participants reported being disgusted by scenarios involving exposure to other people's bad breath, sweat, urine, feces, etc.--their Body Odor Disgust Sensitivity (BODS). 

The researchers also measured participants' authoritarian attitudes on a 15-question Right-Wing Authoritariansm scale (RWA). As the following item from the scale indicates, it taps into desire for a strong leader, support for traditional values, and a punitive attitude towards "others" perceived as a threat:

"Our country desperately needs a mighty leader who will do what has to be done to destroy the radical new ways and sinfulness that are ruining us."

Two separate studies showed a statistically significant link between body odor disgust sensitivity and authoritarianism--desire for a strong leader and traditional values plus a punitive stance towards threatening "others." A third study found a similar link between BODS scores and support for Trump, who was then just a candidate.

Interestingly for those who are still struggling to understand exactly whom Trump appealed to and why, the correlation between BODS and authoritarianism was strong enough to fully explain the link between BODS and support for Trump.

The implication is that, real or feigned, Trump's frequent and emphatic expressions of disgust at a wide variety of targets mirrored, authorized and amplified similar feelings among many Americans--and perhaps got them all the way to the voting booth.

The researchers hypothesize that this link may represent an exaggerated expression of a kind of social immune system--a reflex to avoid potential contamination. They write:

"From a behavioural immune system perspective, prejudice can be seen as a social
discriminatory behaviour partly motivated by the fact that pathogens represent an invisible
threat, and individuals with high levels of disgust sensitivity might be more likely to avoid
foreign people, and to promote policies that avoid the contact with them, because they are
perceived as potentially spreading unfamiliar pathogens, different hygienic or food habits."


They say that forewarned is forearmed. So the next time you see a politician making a disgusted face or voicing his or her disgust towards some other person or group, it might be time to step back, hold your nose, and realize that someone is trying hard to bypass your brain and send a message that goes straight from your nose to your finger pushing a "DONATE" button on your screen or a "VOTE" button in the voting booth.

Politics may stink, but we don't have to let the smells push our buttons, or determine which buttons we push.






Posted by zerospinzone at 5:34 PM No comments:
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Labels: authoritarian, authoritariansim, body odor, disgust, disgusting, politics, smell, smells, stinks, Trump

Wednesday, February 28, 2018

WE'RE SO CLOSE TO ERADICATING POLIO

As followers of zerospinzone.blogspot.com know from previous posts, I'm enthralled by the goal of not just treating or curing diseases, but eradicating them entirely.

Among human diseases, smallpox was the first to be wiped away, with the last case of a natural infection by this once devastating scourge occurring in October, 1977.

Polio, a paralyzing and sometimes fatal disease that struck down more than 500,000 people per year, most of them children, as recently as the 1940s and '50s, will hopefully be the next to go. Starting with the development of the Salk inactivated virus vaccine in the early 1950s and the Sabin attenuated virus oral vaccine in the early 1960s, polio has been eradicated in country after country, continent after continent, through massive, sustained, costly and often extremely difficult public-health efforts.

 An infant receives the oral polio vaccine at a mobile clinic in Afghanistan, February 15, 2017
Credit: World Health Organization (WHO)/ S.Ramo

This enormous international effort has been incredibly successful. So far this year, only three cases of polio have been diagnosed worldwide, all in war-torn Afghanistan. In other words, the wild polio virus that once circulated freely throughout the world, has now been caged and almost completely destroyed, and now may hang on in just one small corner of one country.

It will still take intense surveillance and continued mass vaccination programs to strike the final blow against this deadly disease and ensure that it can not flare up anywhere every again.

But the world is so very close. What an accomplishment it will be.

REA

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Labels: Afghanistan, disease eradication, eradicating, eradication, polio, poliomyelitis, progress, smallpox, update, WHO, World Health Organization

Tuesday, February 27, 2018

TRUMP AND PRUITT'S EPA GUTS RESEARCH ON TOXIC CHEMICALS AND KIDS

I maintain a computer file with hundreds of scientific articles about the effects of toxic substances on children.

Arsenic and lead in drinking water. Pesticides and other Persistent Organic Pollutants in the air we breathe, clothing, furniture, building materials, you name it. Some common drugs taken during pregnancy. Hormones and endocrine disrupting chemicals in food, plastics, toys, just about anything that could go into a child's mouth. Chemicals used in fracking that get into the air and water. Fire retardants, fungicides, and many other classes of chemicals. Not to mention the impact of the cocktail of these chemicals that many people carry in their bodies, in breast milk, in their blood.

 Credit: DES Daughter

These articles detail the impacts of these toxins on developing children still in the womb, on infants, children, teenagers (and adults too). Autism, attention deficits, abnormal brain activity, birth defects, impaired sleep, impaired learning, reduced IQ, disruptions in the reproductive system, infertility, obesity, cancer, breathing problems, kidney and liver damage--all of these and many more impairments and diseases have been linked to various chemicals that find their way into our children's bodies.

Like research on smoking decades ago and on climate change now, much of this research is controversial or marginalized. The suspect chemicals have important uses in agriculture, energy production, medicine, and many other activities, and add billions of dollars to the economy and to the bottom lines of giant corporations. The companies that manufacture and sell these substances are strongly motivated to keep selling them, and are willing to spend huge sums to question, hide or suppress research that threatens their bottom line, carry out or fund research aimed at sowing doubt about such threatening findings; and in many cases demean or threaten researchers who are brave enough to research these links.

Still, this body of research has been used by governments around the world, and by the US, to develop legislation to ban some of the most deadly chemicals, reduce and control the use of many others, and protect the health of children and adults.

In the US, the Environmental Protection Agency (EPA) has been one of the major sources of funding for research on the impacts of known or potential toxins, through its National Center for Environmental Research (NCER). The NCER funded millions of dollars of research on the risks to children from potentially dangerous substances. Until now, that is.

Trump's appointee to head the EPA, Scott Pruitt, has decided to kill the NCER, as announced on February 26, 2018. The gutting of the program is couched as an efficiency measure, but is in line with Trump and Pruitt's goals of reducing regulations and risks for corporations, unfortunately at the expense of America's children.

In 1965, comedian Tom Lehrer satirized the extent of pollution that Americans were then being exposed to in the song "Pollution" on his album That Was the Year That Was. The song opens with:

If you visit American cith
You will find it very pretty
Just two things of which you must beware:
Don't drink the water and don't breath the air!

The EPA was created five years later, in December of 1970. Over the years, it did a lot to clean up America's polluted rivers, lakes, industrial sites, cities and skies. However, under Trump and Pruitt, we seem to be turning back the clock to those bad old days, when, as Lehrer concluded:

So go to the city, see the crazy people there
Like lambs to the slaughter
They're drinking the water
And breathing the air



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Labels: chemicals, children, development, disease, Environmental Protection Agency, EPA., illness, National Center for Environmental Research, NCER, pollutants, Pruitt, toxins, Trump

Thursday, February 22, 2018

Advanced Artificial Intelligence--Friend or Foe

When I learned last December that AlphaZero, an artificial intelligence developed by Google subsidiary DeepMind, had soared from a completely "blank slate" to superhuman play in Chess, Go, and Shogi (a Japanese variant of chess) in a matter of hours, just by playing against itself, I realized that artificial intelligence is advancing far faster than most of us realize, and to superhuman, and potentially dangerous levels of capability.

You can read my description of AlphaZero's explosive mastery of Chess, Shogi and Go on OpEdNews or from an earlier post on zerospinzone.

AlphaZero's prowess led me do a lot of reading and research about the pace of AI progress, especially in the rapidly advancing areas of deep learning by deep neural networks.

 Image from the mind of Google's Deep Dream Generator
Credit: Robert Adler and DeepDreamGenerator

What I found out is that it's much worse than I thought.

Multiple groups worldwide are researching and developing increasingly powerful AI agents. These artificial intelligences have already surged past humans in many specific areas--not just games, but face and pattern recognition, medical diagnostics, reading comprehension, drug discovery and many other areas. Looming just ahead are AIs that will be smarter--possibly many times smarter--than any human in every important area. Not to mention super-intelligent AIs that can design and create other AIs that are even smarter, leading to an "intelligence explosion" whose impacts and risks are impossible to predict.

As several of the experts who have looked into this most deeply have pointed out, less intelligent species--think chimpanzees, gorillas or our close cousins the Neanderthals--typically don't fare well once a more intelligent species emerges.

A few farsighted individuals and groups have started to look into "the control problem"--how we might be able to create superhuman-but-friendly AIs, agents that will keep our best interests at heart even as they grow smarter and smarter. This turns out to be an extremely challenging problem. Meanwhile, hundreds of much better funded research groups--including many developing AI for military use-- are rushing ahead without giving the risks from the AIs they are developing much if any thought.

If you would like to look into this potential existential risk a bit further, here are some resources:

Center for the Study of Existential Risk (Cambridge, UK): cser.ac.uk

Deep dreaming: deepdreamgenerator.com (site where you can create your own “deep dreams.”

DeepMind: deepmind.com

DeepMind Ethics and Society research group: deepmind.com/applied/deepmind-ethics-society/

Eliezer S. Yudkowsky: yudkowsky.net

     “Artificial Intelligence as a Positive and Negative Factor in Global Risk”             (2008)
      Can be downloaded at: intelligence.org/files/AIPosNegFactor.pdf

Future of Humanity Institute (Oxford): fhi.ox.ac.uk

Future of Life Institute (Boston/Cambridge): futureoflife.org

The 23 Asilomar AI Principles: futureoflife.org/ai-principles/

James Barrat: Our Final Invention: Artificial Intelligence and the End of the Human Era (2015)--excellent introduction to these issues

Machine Intelligence Research Institute, MIRI (Berkeley): intelligence.org

Nick Bostrom: www.nickbostrom.com

     Superintelligence: Paths, Dangers, Strategies (2016)--a challenging factual, analytic, and philosophical work examining these developments in depth

OpenAI: openai.com

Pedro Domingos: The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World (2018)

I'd suggest starting with James Barrat's extremely well-researched book, Our Final Invention: Artificial Intelligence and the End of the Human Era.

And for a super-deep dive into the issue, Oxford philosopher Nick Bostrom's Superintelligence: Paths, Dangers, Strategies. 

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Labels: AI, AlphaZero, artificial intelligence, chess, danger, deep learning, deep neural networks, DeepMind, Go, intelligence explosion, neural networks, risk, runaway AI, Shogi, superhuman, superintelligence

Friday, January 19, 2018

SOME FACTS ABOUT GUNS IN THE U.S.

The debate about guns in the United States is clouded by too much rhetoric and too few facts. Slogans like "Guns don't kill people, people kill people," or More guns, less crime," may sound as though they convey useful information, but in fact they just add further cement to already polarized and fixed positions.

Las Vegas welcome sign adorned with flowers
a week after the October 1, 2017 mass shooting 
Credit: Wikipedia 

Readers may make of them what they will, but here are a few facts about guns and how they are used in the U.S.  They come from a study published in the journal Science on 8 December, 2017.

1. The U.S. is an extreme outlier among developed countries when it comes to guns and violence. The chance of being murdered by someone using a gun is 25 times higher in the U.S. than in other well-off countries, and the rate of suicides by gunshot is 8 times higher. A U.S. male between the ages of 15 and 24 is an astonishing 70 times more likely to die from gun violence than his peer in any of the other highly industrialized countries..

2. Death by gunshot is a major public health threat in the U.S., comparable to the number of deaths caused by motor vehicle accidents. One difference is that taking rational steps to reduce the risk of death or injury from motor vehicles is not highly politicized or controversial. The result is that the number of deaths per miles driven has plummeted by a factor of 25 since the 1920s.

3. You might suppose that the government would be interested in supporting research to understand the causes and possible ways to mitigate this important public-health problem, as it does with many other diseases and conditions. You would be wrong. In 1996, Congress passed the Dickey Amendment, which effectively killed the Centers for Disease Control and Prevention (CDC) research program on gun violence.

4.Still, non-government researchers have continued to study gun violence and its prevention. These include researchers at many universities and in at least one state--California.

5. An intensive recent study by public-health and legal researchers at Stanford University, in California, and Duke University, in North Carolina, has established several factual reference points:

     --Add-on sentences for the use of guns in assaults and robberies cut the rate of those crimes by around 5 percent.

     --Laws preventing perpetrators of domestic violence from buying or possessing guns save lives, potentially thousands of them--reducing the murder rate for female intimate partners by 17 percent.

     --States with strict restrictions on carrying concealed weapons have significantly lower rates of violent crime than states with right-to-carry laws. Conversely, states that switch from restrictive to right-to-carry on average see a 9 percent increase in their homicide rates.

     --States with a high percentage of households with guns experience 3.6 times as many civilians killed by police than states with fewer households with guns.

If we have any hope of breaking out of the crippling polarization that prevents rational or even civil discourse on gun control here in the U.S., it must start with facts on which people can agree. Facts do not equal policy. But policy without facts is likely to be bad policy. And when it comes to guns, bad policy can and does cost thousands of lives.

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Labels: add-on sentences, concealed weapons, domestic violence, gun control, gun violence, guns, killings, pollice, research, right to carry, right-to-carry, RTC, U.S., United States, US

Friday, January 12, 2018

INCREDIBLE 3-D FLY-THROUGH OF THE ORION NEBULA

The three stars of Orion's belt and the four tracing his sword are among the most recognizable signposts in the night sky. Astronomers have know for years that the middle "star" in Orion's sword--the Orion nebula--is actually an extremely dynamic system of young stars and the clouds and cocoons of gas and dust from which new stars are still being born.


The constellation Orion
clearly showing Orion's belt and sword
Credit: Mark Mathosian 

Astronomers and visualization specialists at NASA's Universe of Learning program have now gifted us with a remarkable 3-D fly-through of the Orion nebula based on visual images from the Hubble Space Telescope, infra-red images from the Spitzer Space Telescope and state-of-the-art 3-D modeling and image processing.

You can find four versions of the fly-through at this URL. They include one in visible light, one in infrared light, and shorter and longer versions combining the visible and infrared views.

 The Orion Nebula in visible and infrared light
Credit: StSci

Remember, this is not a Hollywood sci-fi mockup, but an accurate 3-D rendition using astronomy's best images of and data about the Orion Nebula. Given that the nebula is estimated to be 24 light-years across, these  video journeys are something no human could actually make; they provide a unique, almost god-like view. Sit back, turn on your speakers, and enjoy the trip.

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Labels: 3-D, fly-through, Great nebula in Orion, HST, Hubble, Hubble Space Telescope, infra-red, infrared, NASA, Orion, Orion Nebula, Spitzer Space Telescope, Sptizer, Universe of Learning, visible

Thursday, January 11, 2018

AN INFECTIOUS IDEA -- A VIRUS-LIKE PROTEIN MAY BE CRUCIAL TO LEARNING AND MEMORY

We've all heard the phrase, "an infectious idea." It turns out that this may not just be a metaphor--new research has revealed that a virus-like protein in all of our brains may be vital for learning and memory.

"If it looks like a duck and quacks like a duck," the saying goes, "it probably is a duck." So, no matter how surprising it is, finding a crucial protein in the brain that looks like a virus and acts like a virus raises the intriguing possibility that our ability to learn and remember may stem from a chance infection of some ancestral four-legged creature by a retrovirus 350 to 400 million years ago.

The protein in question is called Arc. It's found in animals as different as flies, mice and humans. It's been known for some time that Arc is important for learning and memory. Mice lacking Arc forget what they've learned within 24 hours, and lack the kind of brain plasticity that lets young animals, most notably human children, soak up new information quickly and easily. Arc continues to be important for learning and memory throughout life, and impaired Arc functioning is associated with autism, amnesia and Alzheimer's disease.

Arc (long purple proteins inside the perimeter of the vesicle) can encapsulate and deliver its own genetic material to brain cells (light green branching blobs) in a manner similar to the way in which viruses infect host cells.  
Credit: Jacobo Lopez, Yi-Chu Su, Hugo Vaca

Jason Shepherd, a neuroscientist at the University of Utah, and his colleagues first suspected that something was different about Arc when they found that the protein self-assembles into structures called capsids that look like a lunar lander or the HIV retrovirus. Intrigued, they found that not only can the Arc capsid jump from cell to cell like a virus, it also transfers its own genetic material in the form of messenger RNA into the new cell.

Learning takes place when interconnected brain cells are activated at the same time. Intriguingly, the researchers found that when neurons "infected" by Arc are activated, they release newly minted Arc capsids. This suggests that the transfer of this virus-lilke protein from cell to cell may be a previously unknown and unsuspected mechanism for learning and memory.

Neuron expressing Arc and transferring it to other neurons
Credit: Elissa Pastuzyn 

“We went into this line of research knowing that Arc was special in many ways," says the study’s lead author, postdoctoral fellow Elissa Pastuzyn. "But when we discovered that Arc was able to mediate cell-to-cell transport of RNA, we were floored. No other non-viral protein that we know of acts in this way.”

Geneticists have been able to trace back the history of the Arc proteins found in all mammals. Sometime between 350 and 400 million years ago, a primitive four-limbed creature, or tetrapod, was infected by a retrovirus that left some of its genetic material in the animal's DNA. That chance addition to the mammalian genetic code has apparently proven extremely useful, perhaps laying the groundwork for the success of our mammalian ancestors, and even for our remarkable capacity for learning and remembering.

REA
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You can read more about this research at this URL.

The scientific article describing this research can be found in Cell, January 11, 2018.

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Labels: Alzheimer's, amnesia, Arc, autism, brain, learning, memory, mRNA, plasticity, protein, retrovirus, RNA, virus, virus-like

Wednesday, January 10, 2018

WARNING CONCERNING ACETAMINOPHEN IN PREGNANCY

Acetaminophen is one of the most widely used headache and pain relievers in the world. It's sold alone under brand names such as Tylenol and Paracetamol, or in combination with other ingredients  as Exedrin, Dristan and many others.

Credit: iStock

Acetaminophen is officially authorized for use during pregnancy. According to the US Centers for Disease Control and Prevention (CDC), 65 percent of American women use the medication at some point in their pregnancy.

However, several new studies raise red flags for pregnant women and their children.

A new study from Mt. Sinai Health System, in New York City concludes that pregnant women should limit their use of acetaminophen in any of its forms. The study found that expectant mothers' use of acetaminophen in early pregnancy (8-13 weeks) was associated with delayed language development in their daughters when tested at the age of 30 months.

Delayed language development is important in its own right, and because it tends to predict a range of neurodevelopmental problems in children.

""Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy," said Shanna Swan, PhD, Professor of Environmental and Public Health at the Icahn School of Medicine at Mount Sinai, the study's senior author.

Acetaminophen is found in many over-the-counter medications
Credit: Dome Poon


An international team of researchers followed 754 women who were part of the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy study. Both the number of acetaminophen tablets taken early in pregnancy and measured concentration of the drug in the mothers' urine were strongly correlated with girl's later language development.

The effect was striking--girls whose mothers took acetaminophen more than six times in the first 13 weeks of pregnancy were six times more likely to show delayed development of language than girls whose mothers had not taken any of the drug, and the daughters of the 25 percent of mothers with the highest urine levels of the drug were 10 times more likely than those in the lowest 25 percent.

This is the first study to show this effect. As professor Swan points out, further research is needed to corroborate or modify the findings. Still, given the importance of language development in childhood, women who are or may be pregnant should certainly take notice.

In addition, three separate studies, just released, found that a mother's exposure to acetaminophen during pregnancy may reduce the number of eggs tucked away in their daughters' ovaries, and so reduce their eventual fertility. Although these studies were in mice rather than humans, researchers view it as significant for humans as well. "Although this may not be a severe impairment to fertility," says Dr. David Kristensen, at Copenhagen University Hospital, in Denmark, "it is still of real concern since data from three different labs all independently found that paracetamol may disrupt female reproductive development in this way, which indicates further investigation is needed to establish how this affects human fertility."

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The Swedish/Mt. Sinai study appears in the journal European Psychiatry, 10 January, 2018

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Labels: acetaminophen, development, Dristan, Exedrin, girls, headache, language, language development, pain, pain relief, pain reliever, Paracetamol, pregnancy, pregnant women, risk, safe, safety, Tylenol, unsafe, warning

Monday, January 08, 2018

THE "BULLY'S PULPIT"

This post by Les Adler first appeared on OpEdNews, January 5, 2018.

In the past year, Theodore Roosevelt's characterization of the presidency as a "bully pulpit" for moral leadership and political uplift has been twisted into something far different and far more dangerous.

Not content with his campaign of schoolyard name-calling against political rivals ("little Marco," "crooked Hillary"), Donald Trump, as president, has graduated into using his elevated position to issue demeaning taunts about North Korean dictator "little rocket man," to intimidate him, and most recently into declaring twitter-warfare with him by comparing the size of their respective nuclear buttons. A bad joke at best; at worst a terrifying threat of planet-scale nuclear annihilation demeaning to the Office and ultimately destructive of America's remaining stature as a trustworthy world leader.

 
Teddy Roosevelt, who first identified the presidency as a "bully pulpit"
Credit: Martin/(Image by guano)

He has employed that same presidential pulpit to regularly disparage the integrity of entire government agencies such as the CIA, FBI and the Justice Department, railing against responsible government officials and news media ("fake news") when they won't accede to his latest whims or accept his version of "alternative facts." In a stream of attacks against minorities, immigrants and legitimate protestors, he has turned the moral force of the presidency against those who are often most vulnerable, further dividing rather than uniting the nation.

 These are the actions of a bully, the likes of which the country has not seen on the national stage since the meteoric rise and fall of Senator Joseph McCarthy in the 1950's. In that pre-internet world, McCarthy, like Trump today, showed an instinct for manipulating the national media, managing to dominate news cycles and public attention by stoking public fears about foreign and domestic 'enemies' hard at work undermining major national institutions.

Significantly, the career of the country's most infamous demagogue ended not with a bang but with a whimper. Censured at long last by the Senate on December 2, 1954 by a bi-partisan 65-22 vote for inexcusable and insulting" conduct "unbecoming a senator," Joe McCarthy slowly lost political influence, sank deeper into alcoholism, slunk off the public stage and died in 1957 at the age of 48.

His fall followed a three-year reign of terror in which he increasingly misused his position as chair of the Senate Permanent Subcommittee on Investigations to attack, publicly indict and essentially persecute and ruin the names and careers of those called before the committee. Aided by his chief counsel, Roy Cohn, and protected by political allies in congress as well as the climate of fear his attacks engendered, McCarthy's fame soared despite his wild, often unproven charges, use of innuendo, outrageous lies and his technique of bullying and browbeating witnesses.

 Joseph McCarthy and Roy Cohn
Credit: Wikipedia.org/Creative Commons

Two decisive moments in his downfall stand out in the historical narrative, both important lessons to heed in handling bullies of any stature. McCarthy's ultimate unraveling came in an attack on the integrity of the U. S. Army for allegedly coddling subversives and led directly to the nationally televised clash between the Senator and the chief lawyer for the Army, Boston attorney Joseph Welch. In front of an audience of millions, after watching McCarthy attempt to smear a young attorney in Welch's practice, Welch finally pronounced the unforgettable judgment which at long last publicly captured McCarthy as the bully he was, "Have you no sense of decency, sir. At long last, have you left no sense of decency?"

The second also occurred on national television, on March 9, 1954, when the highly respected broadcaster, Edward R. Murrow, directed an entire "See It Now" program to an exposure of McCarthy for the publicity-hungry bully he was. Using McCarthy's own words, Murrow examined and rebutted the Senator's extreme charges and methods, clearly and reasonably laying-out for his national audience the Senator's use of lies, distortions and half-truths--and their corrosive effects on our national life and international reputation.

In summing up, Murrow spoke eloquently both to his era and presciently to those of us in the far future who might be confronting similar challenges:

"This is no time," he stated, "for men who oppose Senator McCarthy's methods to keep silent. The actions of the junior Senator from Wisconsin have caused alarm and dismay amongst our allies abroad, and given considerable comfort to our enemies. We will not walk in fear, one of another. We will not be driven by fear into an age of unreason. We proclaim ourselves the defenders of freedom, wherever it continues to exist in the world, but we cannot defend freedom abroad by deserting it at home."

Senator McCarthy, for all the damage he did domestically and to America's reputation abroad, did not have the power to start a war, much less risk a nuclear "exchange."  President Trump does have that power! And now his intemperate and belligerent tweets from that much-diminished "bully pulpit" have put us all at risk.

It is past time for those in positions of responsibility and power--particularly those in the President's own party--to directly confront the challenge Trump represents in the name of the welfare of the nation and the world.

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Wednesday, January 03, 2018

A TALE OF TWO BULLIES

I'm sure it's just a coincidence that the two bullies who have bothered me the most were both named Donald T.

The first Donald T. was the biggest bully at my elementary school. (I'm not providing his full name in the hope that he's changed). Taller and beefier than most of the kids, he  seemed to enjoy creating fear and causing pain. In class, when the teacher's back was turned, he pulled girls' hair and punched other boys. At recess, he and his mini-gang liked to single someone out, chase him or her down, taunt, push and punch them, and then scatter before a teacher could intervene.


 A bully in action
Credit: http://bullyingproject.com/bullies-and-victims/

I remember reading comments by a naturalist who pointed out that when predatory animals are on the hunt they are not fearful or angry--they don't show any signs of negative emotions. Instead, they are alert, goal-oriented and aroused in a positive way; you might say they're at the top of their game.

Donald T. and his buddies were like that. Singling out the day's victim, the chase, circling their prey, and the pushing and pummeling were clearly fun for them. Especially if someone really panicked or started to cry, the gang's reaction was not shame or remorse, but gleeful laughter.***

My training and career were in psychology. I'm well aware of the characterological propensities, vulnerabilities and unfortunate developmental events that may turn a child into a bully. However, the existence of such contributing factors doesn't provide much comfort to a bully's victims. I'm also very aware--and wary--of what seems to be our natural human propensity to blame victims for what happens to them. So, on balance, I don't find it particularly helpful to empathize with bullies or try to excuse their behavior.

That brings us to Donald T. number two, the bully-in-chief of the United States.

 Trump and followers at a rally
Credit: Gage Skidmore

I never paid much attention to Trump until he emerged as a presidential candidate. But once I saw him in action, all of my bully-alarm-bells went off. Nothing he's said or done since then has changed that first impression (and a lot that he's said and done has deepened and strengthened my belief that he is a damaged, disturbed and dangerous individual).

I recently read an article from the Washington Post by social scientist Bella dePaulo, entitled "I study liars. I've never seen one like Donald Trump," that clarified why I find Trump so disturbing. DePaulo used the Post's Fact Checker feature to study the more than 1,600 lies or "misleading claims" that Trump emitted during his first 298 days in office--about six whoppers per day. The sheer number of lies he told was "remarkable," but, according to dePaulo, what really set Trump apart was the number of "cruel lies, told to hurt or disparage others."

Here's one example:

Donald J. Trump‏Verified account @realDonaldTrump


Vanity Fair, which looks like it is on its last legs, is bending over backwards in apologizing for the minor hit they took at Crooked H. Anna Wintour, who was all set to be Amb to Court of St James’s &; a big fundraiser for CH, is beside herself in grief &; begging for forgiveness!


7:24 AM - 28 Dec 2017

In one tweet, Trump manages to demean and disparage Vanity Fair (on its last legs and bending over backwards apologizing), Hillary Clinton (crooked), and Anna Wintour (beside herself with grief and begging for forgiveness).

Here's another:

Lightweight Senator Kirsten Gillibrand, a total flunky for Chuck Schumer and someone who would come to my office “begging” for campaign contributions not so long ago (and would do anything for them), is now in the ring fighting against Trump. Very disloyal to Bill &; Crooked-USED!

5:03 AM - 12 Dec 2017

Senator Gillebrand is a lightweight, a total flunky, begged Trump for contributions, "would do anything for them," and is disloyal, crooked and used. That's a lot of venom to pack into 140 characters, but Trump has obviously mastered the art.

Trump is especially fond of depicting people as begging him for favors, as documented here.

By now, Trump has bashed through so many norms and revealed his pathologies so blatantly and in so many ways, that the fact that he loves to put others down as a way of building himself up is no surprise, nor that the enormous prestige and responsibilities of the presidency have not caused him to temper his behavior. What's more worrisome is that he seems to revel in the cruelty, which means he's not just a bully but a sadist (for examples, click on these links from Alternet, USA Today, the Irish Times, the Chicago Tribune, the book Fire and Fury, and the DailyKos).

But what I find most concerning is that 35 to 45 percent of Americans remain faithful to the bully-in-chief even as he sneaks money out of their pockets to give to giant corporations and the richest one percent. As of January 5, according to the Rasmussen poll, 44 percent of likely voters approve of Trump's job performance, and a remarkable 29 percent strongly approve.

On my grade-school playground, only a handful of sycophants ran with Donald T., basking in the reflected light of his cruelty. But if a third of the kids had rallied around him, joined him in scapegoating, isolating and tormenting one child after another, modeled themselves after him, my sunny and happy elementary school would have become a dark and dangerous place.

I don't know about you, but I don't like where this train of thought is taking us.

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7/17/18--one place is has already taken us is the inexpressibly cruel separation of parents and children at the U.S border, apparently without any mechanism in place to re-unite them.

10/4/18--we saw another ugly glimpse of the sadism of Trump and many of his supporters in his taunting of Dr. Christine Blasey Ford at a rally in Mississippi. As Atlantic author Adam Serwer puts it, "the cruelty is the point."

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*** For a remarkable example of "the gleeful joy of bullying" check out this video of Representative Marjorie Taylor Greene harassing Representative Alexandria Ocasio-Cortez:

https://twitter.com/i/status/1393208622054842368

or you can watch the whole premeditated sequence in this longer video. The most striking part starts at 10:30:  https://www.youtube.com/watch?v=HK6XEqG3UgE







Posted by zerospinzone at 7:21 AM No comments:
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Labels: Alexandria Ocasio-Cortez, AOC, bullies, bully, bullying, children, cruel, cruel lies, cruelty, Donald Trump, liars, lies, Marjorie Taylor Greene, parents, sadism, sadist, separating, separation, Trump

Monday, January 01, 2018

US POLICE KILLED 1129 PEOPLE IN 2017

The database Mapping Police Violence reports that police in the US killed 1,129 people in 2017; an average of three people every day. The number is unacceptable but not surprising--US police officers have killed more than 1,000 people every year for at least the past three years.

As has been the case for many years, the color of your skin matters a lot, with Blacks, Hispanics and Native Americans being killed a far higher rates than whites, independently of whether or not they were suspected of a violent crime or were armed.

One out of 1,129
 Credit: Vimeo.com

As has also been the case for many years, the US is an extreme outlier compared to other countries. As documented by the Guardian, US police kill more people in a few days than police in other countries do in years.

Our nation's current attorney general, Jeff Sessions, is doing everything he can to make this situation worse. He's ended an Obama-era federal police oversight program that had cut the police killing rate in cities with some of the worst rates of police killings. Trump too is doing his best to make things worse by repeatedly demeaning and besmirching the patriotism of the NFL players protesting police violence, along with the Black Lives Matter movement.

How about a national new year's resolution to save 500 lives by cutting the rate of police killings in half? Even if we were to accomplish that, US citizens would still be at far greater risk of being killed by their police than people in other countries, but at least it would be a start.

It can be done. Studies have shown that police departments that require officers to use all other means before shooting cut their killing rate by 25 percent, as do departments that require that all use of force be reported. Simply banning chokeholds and strangleholds cuts police killings by 22 percent.

It can be done, but not with the kind of leadership currently coming from Washington.

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You can read earlier posts on this subject here and also here.

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Labels: 2017, Black Lives Matter, killing, killings by police, NFL, police, police brutality, police violence, protests, Sessions, Trump, US, violence
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