The Real Risks of the COVID Vaccines

 Anyone following social media could be excused for thinking that the vaccines against COVID-19 are not just ineffective but extremely dangerous. Here are a few of the categorical assertions from a recent post on a nominally progressive news site:

"The COVID vaccines are the most dangerous vaccines in human history. They are 800 times more deadly than the smallpox vaccine, which was the previous record holder. The vaccines have killed over 150,000 Americans and permanently disabled even more. They don't make sense for anyone of any age. The younger you are, the worse it gets. For kids, it is estimated that we kill 117 kids for every COVID death we prevent...”

Credit: Marco Vetch

"So we are 'saving' fewer than 10,000 lives at the expense of over 150,000 (vaccine) deaths. In short, we kill 15 people to save 1. That's incredibly stupid."

“The eminent Dr. Peter McCollough has emphasized: "You are about five times as likely to die of the vaccine than you are to take your risks with COVID-19.”

“A recent medical research article said: "A novel best-case scenario cost-benefit analysis showed very conservatively that there are five times the number of deaths attributable to each inoculation vs those attributable to COVID-19 in the most vulnerable 65+ demographic."

We can now test such frequently repeated claims against actual data:

Currently 454 million COVID-19 vaccine doses have been administered in the US, and 195 million US residents have received two or more of the shots. Logically, if the vaccines were as dangerous as vaccine critics want us to believe, taking 5, 15, or, for children 117 lives for every life saved, those hundreds of thousands of deaths should be showing up somewhere. To put it crudely—show us the bodies.

Here's some striking new research that tells us that those bodies are never going to be found because they simply don't exist.

We already know that COVID-related deaths are consistently far lower among vaccinated compared to unvaccinated people. So the deaths supposedly caused by the vaccines must show up among deaths that are not COVID-related. Unfortunately for vaccine critics (but fortunately for everyone else), a large new study shows that the death rate from all causes other than COVID-19 is significantly lower among vaccinated compared to unvaccinated Americans.

If the hundreds of thousands of deaths from the COVID vaccinations don't show up as COVID-related, or as non-COVID-related, they don't exist. Period. The bodies will never be found because they were never there.

The new research appears in the Morbidity and Mortality Weekly Report (MMWR) of October 29, 2021. It's open access, so you can read the entire article here. (I know from experience that true-blue COVID vaccine critics pre-emptively discount all information from the CDC, JAMA, the New England Journal of Medicine and other "mainstream" sources. So they will doubtlessly discount this study too.)

Researchers at 9 large healthcare organizations across the US extracted anonymized data from the medical records of 6.4 million vaccinated people and 4.6 million unvaccinated people 12 years old or older. The data included vaccination dates, the kind of vaccine received, and subsequent health outcomes, including any deaths. In order to control for generalized vaccine or healthcare avoidance, the group who did not receive COVID vaccination was selected from people who had chosen to get flu vaccinations within the last two years.

 The researchers calculated and compared deaths per 100 person-years at risk between December, 2020 and July, 2021.

The results were striking:

After one dose of the Pfizer mRNA vaccine, vaccinated people's risk of dying from all causes other than COVID-19 was just 41 percent of the risk of unvaccinated people.

After two Pfizer doses, that relative risk went down to 34 percent.

After one dose of the Moderna mRNA vaccine, the non-COVID death risk was 34 percent.

After two doses of the Moderna vaccine, that relative risk went down to 31 percent.

After a single dose of the Johnson & Johnson adenovirus-vector vaccine, the risk of death from all causes other the COVID-19 was 54 percent compared to unvaccinated people.

With the exception of children age 12 -17, for whom the risk of death was equally low regardless of vaccination status, these findings held for all age groups, for men and women, and for all racial and ethnic groups.

The study's understated, but extremely clear conclusion:

“There is no increased risk for mortality among COVID-19 vaccine recipients.”

To restate the implication of these findings from the actual medical histories of 11 million people across the US:

There have not been 363,000 deaths (expected if the vaccines were in fact “800 times more deadly than the smallpox vaccine.”)

There have not been “over 150,000 Americans” killed by the COVID vaccines.

The vaccines are not killing 15 people to save 1.

You are not “5 times more likely to die of the vaccine than … your risks with COVID-19.”

There have not been 5 times the number of deaths from each inoculation compared to COVID among people 65 and older.

It's actually just the opposite. Not only do the COVID vaccines prevent deaths from or related to COVID, they are strongly associated with reduced deaths not related to COVID.

The researchers raise the intriguing question of just how the COVID vaccines lead to these additional lives saved. They suggest three plausible factors—it's possible that people who have chosen to get vaccinated have healthier lifestyles, they may be healthier in general, and perhaps there were some deaths from COVID in the unvaccinated cohort that were attributed to other causes. Further research is needed and is being planned.

Whatever the reasons for the strikingly reduced rates of non-COVID-related death among these 11 million Americans, the fact remains that the vaccines emphatically do not put us at risk, or “only” reduce COVID-related deaths, they actually reduce our risk of dying from causes other than COVID.

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A slightly different version of this article appeared on OpEdNews on 12/1/21.

There is no increased risk for mortality among COVID-19 vaccine recipients.

Let's start with the claim that the COVID vaccines are “800 times more deadly than the smallpox vaccine.” According to the National Library of Medicine, the death rate from smallpox vaccination was one death per million vaccinations. If it's true that the COVID vaccines are 800 times more deadly, then the 454 million COVID shots must have killed 800 x 454 = 363,200 Americans. That's about 45 percent of the 800,000 CoVID-related deaths that have dominated headlines, filled and sometimes overwhelmed hospitals and intensive care units, and orphaned 150,000 to 200,000 children.

If the vaccine critics want to be taken seriously—show us the bodies.

Another claim in the same paragraph: “It is estimated that we kill 117 kids for every COVID death we prevent.”

[TK—go directly to new data about deaths, put the discussion of VAERS, etc. below]

When pressed, the vaccine critics start by citing VAERS, the US Vaccine Adverse Event Reporting System. VAERS has received over 10,000 reports of deaths following COVID vaccinations. VAERS emphasizes that:

“FDA requires healthcare providers to report any death after COVID-19 vaccination to VAERS, even if it’s unclear whether the vaccine was the cause. Reports of adverse events to VAERS following vaccination, including deaths, do not necessarily mean that a vaccine caused a health problem.”

Despite that unambiguous warning, vaccine critics typically take the number of deaths reported to VAERS as definitely caused by the COVID vaccines, and then multiply that number by a large factor—up to 100--based on assumed under-reporting.

There are many reasons why the VAERS data can't be taken literally, but a basic one is the background rate of deaths that would be expected in the weeks following the 450,000,000 vaccinations Americans have received—or 450,000,000 events of any kind.

You can check the math at the end of this post, but the fact is that if you picked 450,000,000 random weeks in the lives of Americans, you would register more than 75,000 deaths. In other words, it's basically impossible to know if any of the deaths reported to VAERS following COVID vaccinations are caused by the shots, related to the shots, or just part of the much larger number of deaths that occur among hundreds of millions of people any given week. Clearly, multiplying a meaningless number by 15, 50 or 100 doesn't make it any more meaningful.

Vaccine critics perform another trick to minimize the effectiveness of the vaccines. They cite a CDC report that just 6 percent of COVID-related deaths are in people with no known risk factors (such as obesity) or co-morbidities (such as diabetes). They then assume that the remaining 94 percent of COVID-related deaths must actually be from something other than COVID. This trick reduces the number of COVID deaths by 94 percent, so currently from 770,000 down to 46,200.

So, with a little hand waving and a few abracadabras, the vaccine critics manage to “find” 150,000 or more deaths from the vaccines compared to only 46,000 deaths from COVID itself. Clearly we should be far more scared of the vaccines than by COVID, right?

Luckily, we have some new and much more reliable data about the alleged dangers of the COVID vaccines.

How many Americans can be expected to die in the week following a COVID-19 shot (or in the week following any given event)?

About 2,855,000 Americans die every year. That's 870 per 100,000 person-years or 16.7 per 100,000 person-weeks.

Let's suppose that vaccine administrators report any deaths that occur within one week following a COVID shot. That means that any deaths among 454,000,000 people for one week, or 450,000,000 person-weeks would potentially be reported. But we would expect 16.7 natural deaths per 100,000 person-weeks, or 167 deaths per million person-weeks, so 167 x 454 = 75,818 natural, but potentially reportable deaths.

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Who shouldn't get vaccinated? The informed part of informed consent.

 Ten months after the vaccines became available, we now have meaningful data that can guide people deciding if they should or shouldn't get themselves or their children vaccinated against covid.

The best available data about the actual risks of the mRNA vaccines--specifically the Pfizer/BioNTech shots--come from a joint Israeli-Harvard Medical School study evaluating the medical records of more than 1.6 million people, half of whom received two Pfizer jabs while half remained unvaccinated. I reported on this study here, and you can find the peer-reviewed paper itself, published in the New England Journal of Medicine, here.

Of course. But what are the actual risks and benefits?

Credit: Nick Youngson

The study found that just five side-effects occurred more frequently in the vaccinated groups in the six weeks following vaccination relative to a comparable time period for the unvaccinated group. These included swollen lymph nodes (78.4 additional cases per 100,000 people), shingles (15.8 extra cases per 100,000), appendicitis (5 additional cases per 100,000), Bell's palsy (3.5 additional cases per 100,000) and myocarditis (2.7 additional cases per 100,000, almost all in young men).

If we add all those side-effects together we find an incidence of 105.4 per 100,000 fully vaccinated people.

It's worth noting that those symptoms vary in seriousness. The most frequent--swollen lymph nodes--is a predictable, rarely serious, reaction to vaccination, while the remaining four potentially more serious conditions represent a total of just 27 additional cases per 100,000 vaccinated people.

To keep things simple and clear, you can safely estimate that if you get two rounds of the Pfizer vaccine, your risk of suffering any reaction worse than a sore arm is around 1 in 1000, and your risk of a serious side-effect such as shingles or appendicitis is around 1 out of 3700.

We can compare these risks to the risks from covid itself in a variety of ways. Here are several that readers may find helpful:

Risks from covid in the Israeli-Harvard study: Among the 800,000 participants who remained unvaccinated, a significant number contracted covid. As is typical of covid, not all of those developed serious symptoms. However, far more did experience significant symptoms and sequelae from covid than were seen in their vaccinated peers. These included cardiac arrythmia (166 extra cases per 100,000), acute kidney injury (125.4 extra cases per 100,000), pulmonary embolism--a blood clot in the lung--(61.7 extra cases per 100,000), deep-vein thrombosis (43 extra cases per 100,000), myocardial infarction--a heart attack--(25 extra cases per 100,000), myocarditis (11 extra cases per 100,000), pericarditis (10.9 extra cases per 100,000) and intracranial bleeding (7.6 extra cases per 100,000).

So, in the same 6 week period, the unvaccinated group suffered serious, very serious or potentially fatal symptoms such as acute kidney injury, pulmonary blood clots or heart attacks at a combined rate of 443 per 100,000. That's more than four times the rate of all the vaccine side-effects combined, and 16 times the rate of the potentially serious vaccine side-effects.

Risk of contracting covid in the US as a whole. As of 10/18/21, there have been 45,798,599 recorded covid cases in the US. That's a case rate of 13,733 per 100,000 people, accumulated over 22 months. It's not possible to predict the exact course of the pandemic going forward, but for the average American the risk of contracting covid, say in the next 12 months, is probably 50 or 60 times higher than the risk of any side-effect from the vaccine, and several hundred times higher than the risk of any of the more serious side-effects.

As critics of covid vaccination point out, many covid cases are relatively mild. However, in the US over the course of the pandemic so far, about one out of every 20 people who contracted covid got sick enough to require hospitalization.

Risk of covid hospitalization in the US as a whole. As of 10/18/21, the cumulative covid hospitalization rate in the US reached 694 per 100,000. That implies that the average US resident is 6.6 times more likely to have been hospitalized because of covid than they would have been at risk for any negative reaction to the vaccine, and 26 times more likely to have been hospitalized from covid than to have risked a serious reaction to the vaccine.

Again, the first 22 months of the pandemic don't tell us what the next 22 months will bring, but the risk continues, especially among the unvaccinated.

Again, vaccination critics point out that "covid has a 99 percent survival rate." That's not quite true. In the US so far, 1.6 percent of recorded covid cases have resulted in recorded covid deaths. We can now compare that to the risks from vaccination.

Risk of death from covid in the US as a whole. As of 10/18/21 the cumulative rate of deaths from covid hit 224.5 per 100,000 people. That means that on average, a US resident is 2.1 times more likely to have died from covid since the start of the pandemic to date than to have risked any negative reaction to a vaccine, and 8.3 times more likely to have died as a result of covid than to have risked one of the serious reaction to the vaccine.

Risk of covid deaths state by state. As of 10/18/21, five states had cumulative covid death rates less than 105 deaths per 100,000 population. Those are Oregon (99), Utah (96), Hawaii (87), Alaska (59) and Vermont (55). For residents in those states, which comprise just three percent of the US population, the odds of having died from covid so far in the pandemic are somewhat less than the risk of having any negative reaction to the vaccine, but still two to three times higher than the risk of one of the serious vaccine side-effects. Even in those states, however, the risk of hospitalization from covid is significantly higher than any of the risks from the vaccine.

The remaining 97 percent of Americans live in states where the risks of contracting covid, becoming seriously ill, being hospitalized or dying from covid are greater than the risks of any negative sequelae from the vaccines.

Risk of covid deaths county by county. You can check your county's cumulative covid death rate on this map. If you're in one of the darker blue counties--most of which have very small populations--the cumulative death rate per 100,000 people is less than the risk of side-effects from the vaccine. Still, unless your county's cumulative death rate is less than 12 per 100,000, as it is in Orange County, Vermont (population 29,000) or Skamania County, Washington (population 11,066), your risk of hospitalization from covid is higher than any risk from the vaccine.

Risk of covid deaths from breakthrough infections: We now know that vaccine-induced immunity fades over time, and that the delta variant in particular is causing a significant number of fully vaccinated people to fall ill. However, the vaccines are still highly protective against severe illness and death. Perhaps the most striking statistic is that out of 187,000,000 fully vaccinated Americans, 7,178 have died from covid, or just 3.8 per 100,000. That's less than 6 percent of the 124,000 Americans who have died from covid since mid-July, when the delta variant became predominant.

In summary, for the large majority of Americans, the risks of getting covid, suffering one or more of the serious impacts of covid, having to be hospitalized because of covid, or dying from covid are all far higher than the risks of any side-effect of the mRNA vaccines, and, even against the delta variant, the vaccines remain highly protective against severe illness or death.

What about children?

There is one group, however, for whom this may not be true. As many critics of covid vaccination have pointed out, the risks from covid are significantly lower for young people. For example, the cumulative covid death rate for children under 15 is less than 5 per 100,000, comparable to the death rate for fully vaccinated adults. For 16 and 17 year-olds it's 9 per 100,000, and from 18 through 29, 16 per 100,000. If we were just comparing the risk of dying from covid to the much less serious but documented risks from the mRNA vaccines, one could potentially come down on the side of not vaccinating young children and teenagers.

The picture changes if we include the risk of children needing to be hospitalized because of covid. The cumulative covid hospitalization rate for children 0 through 4 is 87 per 100,000, and from 5 through 18, 51.8 per 100,000. These are less than the risk of any side effects of the vaccines, but higher than the risks of serious side effects. Luckily, young children are less likely to be severely sickened or to die from covid than adults, but a significant number do need to be hospitalized.

Safety and efficacy trials of covid vaccines for children from 5 through 11 are currently taking place, and the White House has announced plans to promote vaccination of children ages 5 through 11 once a children's vaccine is approved. We should have more data specific to that age group within the next few months.

Individual risks vs. social responsibility

The risk ratios discussed above refer to individual risks. That is, one could decide to be vaccinated or not based only on comparing one's own risk of contracting covid, or of requiring hospitalization, or of dying vs. the known risks from the vaccine. However, public health authorities point out that, much like choosing to wear a mask, getting vaccinated doesn't just protect the person getting the jab, it also protects others by reducing the likelihood that that person will infect others. This multiplicative factor becomes significant when large numbers of people in a population remain unvaccinated, and so provide a continuing medium for the virus.

Currently, 43 percent of the US population remain unvaccinated, or more than 143 million people. Around half of those are adults who would incur low risks from vaccination yet could protect themselves and others by doing so. As long as they choose not to get vaccinated, they remain a big, wide playing field across which the coronavirus can continue its advance.

Best data yet on the actual risks of the Pfizer mRNA vaccine

Many people don't trust even repeated assurances from official sources that mRNA vaccines like the Pfizer/BioNTech Covid shots are safe. In fact it's not unusual for opinion leaders opposed to these vaccines, and their followers, to warn that the Covid vaccines are extremely dangerous and have already caused high levels of serious illness and thousands of deaths. Millions of Americans appear to be far more afraid of the vaccines than of the Covid virus itself, and continue to refuse vaccination.

                                                                 Anti-vaccine protester

Credit: Fibonnaci Blue/Flickr

A new, peer-reviewed study appearing in the New England Journal of Medicine injects solid data into this fraught debate. The study provides an accounting and analysis of adverse events that occurred among more than 800,000 people within 42 days of receiving the Pfizer vaccine in Israel between December 20, 2020 and May 24, 2021, compared to an equal number of carefully matched peers who remained un-vaccinated, and to 173,000 peers who were diagnosed with Covid during the same time period. All the data came directly from anonymized medical records.

It's the largest controlled, peer-reviewed study of the side-effects of the Pfizer vaccine to date--nearly 40 times larger than Pfizer's phase III study--and provides the most accurate and detailed evidence to date of its risks when administered to large numbers of people on a national basis.

Anyone interested in reading the full research paper, carried out by researchers at the Clalit Institute in Israel and Harvard Medical School, can find it here.

The study evaluated 25 potentially serious adverse effects that earlier studies and clinical experience since the vaccines were released had identified as possibly linked to the Pfizer or other Covid vaccines, or to Covid itself. It did not look at mild, short-lived symptoms that typically accompany many vaccinations, such as fever, tiredness, or soreness near the injection site. It also did not attempt to evaluate any potential long-term effects.

Results:

Of the 25 adverse effects studied, 5 appeared more frequently following vaccination than they did in the same time period in the group of matched, but un-vaccinated peers:

Myocarditis--inflammation of the heart muscle--was 3.24 times more frequent in the vaccinated vs. un-vaccinated groups. However, since the incidence was low overall, that meant just 2.7 extra events per 100,000 people. In this study 91 percent of cases occurred in young men.

Lymphadenopathy--swollen lymph nodes--were 2.43 times more frequent among vaccinated compared to un-vaccinated people, appearing in 78.4 more cases than expected per 100,000. Swollen lymph nodes can be a sign of a serious condition such as cancer, but usually are simply an indication that the body is mounting an immune response.

Herpes zoster--shingles--was 1.43 times more frequent in the vaccinated group, and accounted for 15.8 additional cases per 100,000 vaccinated individuals.

Appendicitis occurred 1.4 times more often in vaccinated than unvaccinated individuals, adding 5 cases for every 100,000 people.

Bell's palsy--dysfunction of a facial nerve--occurred 1.3 times as often among the vaccinated group, but was also rare, accounting for 3.5 extra cases per 100,000 vaccinated individuals.

An unexpected finding was that vaccination lowered the risk of some of the adverse effects being studied, compared to the un-vaccinated group. Those included acute kidney injury, intracranial bleeding, anemia, and lymphopenia--low levels of white blood cells. The researchers suspect that those benefits appeared because of un-diagnosed Covid cases among the 800,000 un-vaccinated participants, which raised the incidence of those conditions--known complications of Covid-- in the un-vaccinated group.

As is true of almost any medical intervention, this study shows that the Pfizer/BioNTech mRNA vaccine is not risk-free. More importantly, the study gives us a clear measure of just what the vaccine's short- to medium-term risks are. Out of 25 potential side effects, 5 appeared at higher rates in the vaccinated vs. un-vaccinated groups. Of those, the most most serious was myocarditis, which added just 2.7 cases per 100,000, and the most frequent, which added 78 cases per 100,000, was not particularly serious--swollen lymph nodes.

In order to provide further context for those risks, the researchers looked at the same 25 potential adverse effects among 173,000 un-vaccinated study participants in the 42 days after they were diagnosed with Covid. The results reflect many of the all-too-well-known risks of Covid infection:

Cardiac arrythmia--3.8 times more frequent; 166 extra cases per 100,000

Acute kidney injury--14.8 times more frequent; 125.4 extra cases per 100,000

Pulmonary embolism--blood clot in the lungs--12.4 times more frequent; 61.7 extra cases per 100,000

Myocardial infarction--heart attack4.47 times more frequent; 25 extra cases per 100,000

Deep-vein thrombosis--3.78 times more frequent; 43 extra cases per 100,000

Myocarditis--18.3 times more frequent; 11 extra cases per 100,000

Pericarditis--5.39 times more frequent; 10.9 extra cases per 100,000

Intracranial bleeding--6.89 times more frequent; 7.6 extra cases per 100,000

Relative risks from Pfizer vaccination vs Covid infection

Credit: Noam Barda et al./NEJM

The vaccine is not risk free, but equally clearly, it does not cause anything like the degree or kinds of risk that anti-vaccination advocates and believers warn of. And the risks from the vaccine pale in comparison to the far higher risks from a Covid infection.

Here's what Dr. Ran Balicer, the study's lead author, concludes:

"These results show convincingly that this mRNA vaccine is very safe and that the alternative of 'natural' morbidity caused by the coronavirus puts a person at significant, higher and much more common risk of serious adverse events. These data should facilitate informed individual risk-benefit decision-making, and, in our view, make a strong argument in favor of opting-in to get vaccinated, especially in countries where the virus is currently widespread."

I'd add that the United States, which leads the world in Covid cases and deaths, qualifies as one of those countries.

If you want to compare your own risks from the vaccine with your risks from Covid, here's an approach:

If you're in the US and you're not vaccinated, as a rough approximation you have about a one percent chance--1000 out of 100,000 people--of getting Covid in any given six-week period. 

If you're vaccinated, your odds are somewhere between 10 and 20 times better, depending on where and with whom you live, work and recreate.

Six weeks is the same length of time used in the above study, so you can get an idea of your chance of developing any or all of the Covid complications that the study quantified.

To those conditions you can add yet another risk. Over the course of the pandemic in the US, 1.6 percent--1600 out of every 100,000 people--who were diagnosed with Covid died from it.

So, as a first approximation, your chance of coming down with Covid during a given six-week period--and dying from it--is about the same as your chance of getting a case of shingles within six weeks of a Covid vaccination.

From what I hear, shingles isn't fun, but dying is worse.

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REA 9/8/21

STILL DEBATING A COVID VACCINE? HERE'S SOME CRYSTAL-CLEAR DATA FOR YOU

As of the end of August, 2021, 51 percent of the US population have been fully vaccinated for Covid-19. That means that 49 percent have not, despite the vaccine being widely available and free. Still, 61 percent have gotten at least one shot, so that leaves "only" 39 percent of the US population who have so far chosen not to seek or accept Covid-19 vaccination.

That means that more than 129 million Americans remain un-vaccinated, giving the SARS-CoV-2 virus, and especially the highly contagious delta mutant more than enough unprotected targets to continue to cause widespread illness, hospitalizations and death. Those 129 million unvaccinated people also comprise an enormous human petri dish in which the virus can continue to multiply and mutate.

Vaccination vs. hospitalization by state

Credit: NYT

Just in case some of those 129 million might be amenable to real-life, on-the-ground data about the life-saving benefits of the vaccine, here are some brand-new, nation-wide county-by-county research findings:

                                                                          Credit: Jeffrey Harris, MD

Jeffrey Harris, a physician and emeritus professor of economics at the Massachusetts Institute of Technology, gathered data on vaccination rates, Covid-19 case rates and Covid-related hospitalizations in the 112 most populated US counties, a total of 147 million people. He used vaccination data as of mid-July, 2020 and compared them to Covid cases and hospitalizations between July 30 and August 12. You can read a pre-print of the research report here.

The results are striking. 

In the 56 counties in the lower half of the vaccination range, there were 548 cases per 100,000 population during the two-week study period, but just 281 cases per 100,000 in the 56 counties in the upper half of the vaccination rates. 

People in the less-vaccinated counties suffered 1.95 times as many diagnosed Covid-19 cases than people in the more-vaccinated counties.

A ten percent increase in vaccination rate correlated with a 28.3 percent reduction in Covid-19 cases.

The difference in Covid-caused hospitalizations in less- compared to more-vaccinated counties was even more dramatic. In the 56 less-vaccinated counties there were 55.4 hospitalizations per 100,000 people during the two-week study period, compared to 20.5 per 100,000 in the more-vaccinated counties. 

That means that for every hospitalization in the more-vaccinated counties, there were 2.7 hospitalizations in the less-vaccinated ones.

A ten-percent increase in vaccination rate correlated with a whopping 44.9 percent decrease in Covid hospitalizations.

So what's the bottom line of this large, detailed nationwide study? Basically, any region that can get 10 percent more of its citizens to get vaccinated can expect to cut its Covid case rate by 28 percent and its Covid hospitalization rate by 45 percent.

Lets translate those reductions in Covid cases and hospitalizations into lives saved:

In the US to date, we've suffered 39,662,129 confirmed Covid-19 cases. Among those, 2,675,000 have been hospitalized and 654,668 people have died. 

That means that for every 100,000 US cases, we're likely to see 1650 deaths. 

Thanks to an incredibly quick learning curve within the medical profession, the percentage of Americans who survive after being hospitalized for Covid-19 increased from 78.9 percent in early 2021 to 93.5 percent in August. Still, that means that even now the death rate for hospitalized Covid patients is 6.5 percent, meaning that out of every 100,000 Americans hospitalized for Covid, 6500 are likely to die.

As of the end of August, 2021, the US is registering more than 140,000 new Covid cases per day, or 980,000 per week. We're seeing an average of 12,297 new hospitalization per day, or 86,079 per week, and 1163 deaths per day, or 8,141 deaths per week.

Looking just weeks into the future, this study tells us that if just 10 percent of the 129,000,000 un-vaccinated Americans were to get vaccinated, we could avoid approximately 275,000 new Covid-19 cases, prevent 38,650 hospitalizations, and save at least 2500 lives--every week!

Dr. Harris believes we can do this. He says that among his patients he has encountered many "reasons" for not getting vaccinated. He recognizes that some people are "encapsulated in a misinformation bubble from which there seems to be no escape." Others, however, may be reachable, especially if there are tangible, real-life consequences to not be being vaccinated, such as loss of a job or not being able to enter restaurants or other businesses. 

"I expect many will come around," he says. Let's hope he's right.

Worth getting the jabs? You decide.

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REA/8-29-21

Vaccination rates ranged from below 30 percent in three counties in Georgia to over 65 percent in several counties in Maryland, Massachusetts, California and Washington. 

VOTING FOR COVID

If we needed any proof that people's political beliefs shape their reality, this graph from the New York Times provides it:

Credit: NYT, 4/18/21

On the left, appropriately, are the states in which more people voted for Biden in 2020, and on the right, states with more Trump voters. Vaccine hesitancy rates range from less than 10% in true-blue Vermont and Massachusetts to over 30% in true-to-Trump Wyoming. The Times didn't provide a regression line or a correlation coefficient, but having dealt with lots of graphs of this kind, I can say that it's the kind of distribution any researcher would be thrilled to see. 

We're now seeing real-world data showing that fully vaccinated Americans have about one chance in 10,000 of contracting COVID-19, while their un-vaccinated fellow citizens have close to one chance in 10 of catching the virus, and among those who do, close to two percent will die. If the political beliefs reflected in this chart continue to determine vaccination rates, we're going to see two Americas. One that's highly vaccinated, where there's low risk of catching COVID, and where people can return to their normal personal, social and economic activities.  In the other, poorly vaccinated America, people may also be returning to their normal activities, but they'll be doing so with a continued high risk of illness and death from COVID.

Will that contrast wake people up or change many minds.? I doubt it.  As evidence, check this story of death-by-denial, although it's from Norway, not North Dakota.

COVID-19 UPDATE FROM JOHNS HOPKINS UNIVERSITY--4/16/21

"Even though we feel we've moved on, the pandemic hasn't."

Credit: CDC

I just tuned into the latest Covid-19 update from experts at Johns Hopkins University. Epidemiologist William Moss and Professor of Public Health Jennifer Nuzzo brought us up to date on the vaccine rollout, vaccine safety--especially the Johnson & Johnson blood-clot issue, and the current rates of infection across the US.

They point out that the CDC is evaluating the J&J problem and will meet and make recommendations a week from today. The blood clots that have been reported are very serious but extremely rare--about one per million, so the risks of the J&J vaccine are far less than the benefits. Still, Moss and Nuzzo are concerned that this will be a major setback for vaccine acceptance in the US and worldwide. "The next big problem will be addressing vaccine hesitancy," Nuzzo says.

Concerning the pandemic their bottom line was clear: we need to continue to be very careful.

Some quotes:

Moss:

     "Daily case numbers are still dangerously high."

     "We have to maintain our vigilance and hold the line a while longer."

Nuzzo:

     Even though we feel we've moved on, the pandemic hasn't.

DON'T TELL THE ANTI-VAXERS--AFRICA HAS NOW BEEN DECLARED WILD POLIO FREE

In a celebration-worthy achievement, the wild polio virus has now been eradicated across the entire African continent. The August, 2020 victory declaration follows four years without a single case of the deadly paralytic disease caused by the wild polio virus anywhere in Africa.

This represents an enormous success for the decades long worldwide program, led by the World Health Organization, the United Nations Children's Fund and the Rotary Foundation, to eradicate polio worldwide.

Child receiving oral polio vaccine--Credit: UNICEF 

There are three types of wild polio virus. Of these, two have been eliminated worldwide, and now exist only in laboratories. The remaining virus, Type 1, survives in just two countries, Pakistan and Afghanistan, where it has sickened 105 people, mostly children, so far this year.

When the global polio eradication initiative kicked off in 1988, an estimated 350,000 people were paralyzed or killed by poliomyelitis every year. In the United States alone, in 1952, there were more than 57,000 cases, more than 21,000 leading to paralysis, and more than 3,000 deaths. 

While the current near-eradication of polio represents one of humanity's greatest successes in disease control, much more work remains. The oral polio vaccine that has been the core of the eradication program relies on live, but weakened rather than inactivated poliovirus. Very rarely, the weakened virus can accumulate mutations that allow it to cause disease outbreaks again. In recent years there have been as many or more vaccine-derived polio cases than those caused by the wild virus. 

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The end game--finally eradicating the wild virus everywhere while concurrently stopping the transmission of vaccine-derived cases is complicated but within reach.

In the meantime, for the first time in human history, people on six of Earth's continents--more than 90 percent of the world's population--are free from this deadly disease.

 

POLIO STRIKES BACK--ERADICATION ENDGAME SURPRISINGLY DIFFICULT

This has been a very mixed year for the global polio eradication campaign.

What the global polio eradication campaign

wants never to happen again

The good news is that two of the three strains of wild poliovirus have been conquered; they no longer exist except in laboratories.

The mixed news is that the remaining wild poliovirus only exists in two countries, Afghanistan and Pakistan. However, the number of cases in both countries, especially in Pakistan, has been higher than in 2018. The two countries suffered 125 cases of polio compared to just 33 last year, 101 of those in Pakistan. In both countries, strife, insecurity and anti-vacccination propaganda and rumors have enabled the virus to hold on.

The bad news is that the number of people--mostly children--sickened by poliovirus that has mutated back to a virulent form from the live-but-attenuated polio vaccine has more than doubled since 2018. This back-mutation only occurs in one person out of an estimated 2.8 million, but since 450 million children are getting the attenuated vaccine every year, a significant number of cases are inevitable as long as the oral vaccine remains in wide use--unless the surrounding population has a very high rate of "herd immunity." There were 241 such cases in 2019 vs. just 104 in 2018.

The solution is complex, but at hand. In part, it depends on the rapid release of an oral vaccine against the type 2 poliovirus, which is expected to be less likely to mutate to a virulent form. You can read about the global polio endgame strategy here. Plans and resources are in place to make this transition, and the intense, decades-long global campaign to wipe out this deadly disease once and for all will succeed, even if not quite as quickly as hoped.

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Tightening the noose on the polio virus

Not long ago, the virus that causes the paralyzing, often deadly disease polio circulated freely worldwide, crippling or killing half a million people every year, including thousands in the U.S. and Canada.

The mid-20th Century development of the Salk and Sabin polio vaccines gave mankind the tools needed to eradicate this dreaded disease. It's taken 7 decades, but the worldwide campaign to wipe out polio, spearheaded by the UN's World Health Organization and UNICEF, Rotary International, the US Centers for Disease Control and The Gates Foundation, is closing in on the polio virus' last strongholds, Afghanistan and Pakistan.

5, 4, 3, 2, 1, 0! Let's end this terrible disease

Credit RIBI Image Library

So far this year, polio has only sickened five children, three in Afghanistan and two in Pakistan. At the same time, 116 million were vaccinated. With such an active monitoring and vaccinating program, the total eradication of polio is in sight.

That will represent just the second human disease to be complete eradicated. Another deadly viral scourge, smallpox, was completely eradicated nearly four decades ago through a similar worldwide campaign.

The eradication of polio will represent a second great achievement for mankind.